X-Ray diffraction structure of Cu(II) and Zn(II) complexes of 8-aminoquinoline derivatives (TDMQ), related to the activity of these chelators as potential drugs against Alzheimer's disease

TDMQ chelators have been designed as drug-candidates for the regulation of copper homeostasis and reduction oxidative stress in brain Alzheimer's patients. To achieve suitable biological properties high Cu(II) selectivity a zinc-rich medium, ligands must meet critical coordination chemistry requirements related to structures CuII-TDMQ complexes. The correlation between X-ray diffraction Cu- Zn-TDMQ complexes their physicochemical should therefore help draw pertinent correlations structure drug-candidates, select most promising ones studies. Here we report single crystals Cu-TDMQ36, zinc TDMQ35, TDMQ36 TDMQ22. Comparison with already reported other then allows specify requirement potentially more efficient drugs.